T. Johnson

Antibiotic treatment course duration has for decades been dictated by two questionable ideas: first, that longer courses are more effective at curing bacterial infections; second, that longer courses are less likely to lead to drug resistance. Recently, the “shorter is better” movement has challenged the received wisdom, showing shorter-duration antibiotic courses provide similar cure rates, fewer antibiotic-related harms, and possibly less contribution to of antibiotic resistance for common infections. Yet, physicians typically still prescribe longer courses of antibiotics than clinical guidelines recommend. This is ethically unacceptable. In this paper, we argue that prescribing physicians are ethically obligated to prescribe shorter antibiotic courses, given that prescribing physicians bear duties both toward their patients and to protect public health. We rebut objections to our argument and furthermore argue for an ethical obligation of physician-researchers to conduct further trials comparing the shortest current evidence-based course of antibiotics with courses that are even shorter.

Controversy exists over how to ethically distribute health care resources and which factors should determine access to health care services. Although the US has traditionally used a market-based private insurance model that does not ensure universal coverage, the Patient Protection and Affordable Care Act in the United States aims to increase equitable access to health care by increasing the accessibility, affordability, and quality of health care services. This article evaluates the impact of the ACA on equitable mental health care delivery according to access factors that can hinder or facilitate the delivery of mental health services based on need. The ACA has successfully expanded coverage to millions of Americans and promoted coordination and access to mental health care; however, financial and non-financial access barriers to mental health care and access disparities remain. Reform efforts should not undervalue the gains that the ACA has made but should attempt to balance considerations of cost and increasing free-market mechanisms with decreasing remaining health care disparities.

We often use certain terms as if, in using them, they contain a decided moral judgment of an action. Especially in public health ethics, this is not always the case, as shown most starkly by recent (mis)use of the terms “solidarity” and “coercion” to label, and thereby judge, public health actions responding to the COVID-19 pandemic. We analyze the terms solidarity and coercion, and argue that they cannot be used alone as moral judgements of public health actions. Rather, they are better considered as descriptive terms that are merely frequent proxies for normative terms such as justice or utility. We illustrate our argument by reference to three case studies: school reopenings in the USA, mandatory isolation measures in the UK, and vaccine distribution within the EU.

Formal verification aims to prove whether models satisfy specifications, such as showing a program does what its designer intended. Formal verification is a promising approach that can be used to establish safety, security, and trustworthiness specifications of AI systems. However, to realize the potential societal benefits AI promise, we also need transdisciplinary approaches bridging the gamut from computer science and engineering, the broader sciences, as well as the arts, humanities, social sciences, law, business, and beyond to ensure its development involves all perspectives and voices.My personal AI mission: To develop formal verification methods to help establish and assure the safe, secure, and trustworthy development and use of AI, especially in the context of safety-critical systems such as autonomous cyber-physical systems (CPS).

Molecular HIV surveillance, involving the collection and analysis of HIV genome sequences, has become an integral part of public health programmes in high‐income countries. By employing phylogenetic analysis, molecular HIV surveillance can identify individuals and their positions within networks of HIV transmission. While the primary aim of molecular surveillance is to yield public health benefits, such as linking people to care and reducing transmission, it also poses risks and potential infringements on individual privacy and liberty. This paper examines the ethical implications of using phylogenetics to identify individuals involved in multiple transmission events in high‐income countries. Although public health responses tailored to such individuals can significantly reduce further transmission, these individuals often face multiple intersecting vulnerabilities and bear the greatest risks associated with molecular surveillance. We analyze the risks related to privacy, stigma, mistrust, criminalization, and liberty infringements, alongside the benefits of preventing further transmission and increasing healthcare engagement for people living with HIV. We conclude by outlining plausible and ethically acceptable policy options for molecular surveillance practice.

The papers contained in this collection were presented at the 24th Amsterdam Colloquium, organised by the Institute for Logic, Language and Computation (ILLC) at the University of Amsterdam, December 18–20, 2024. The Amsterdam Colloquia aim at bringing together linguists, philosophers, logicians, cognitive scientists, and computer scientists who share an interest in the formal study of the semantics and pragmatics of natural and formal languages. Besides the general programme, the 2024 edition featured two workshops. First, “Dynamic and Inquisitive: Themes from the Work of Jeroen Groenendijk”, dedicated to the memory of Jeroen Groenendijk. Second, “Identifying and Explaining Universals of Semantics”. The 2024 edition also included the Beth Lecture, jointly organised with the E.W. Beth Foundation. The programme included 7 invited talks, 34 contributed talks, and three poster sessions with 24 contributed posters.

This article is an attempt to explore the theme of ‘humanhood’ in the Fourth Gospel. The most important questions to be posed at the outset are the following: who is the model human presented in the gospel as per the Johannine community standards? How can a person acquire humanhood status according to the Johannine community? The divine and human interaction in the life and ministry of Jesus dynamically introduces the life ethics and mission aspects of the Johannine community. According to the Johannine community standards, people can achieve ‘humanhood’ status exclusively in relation to Jesus. As the community of John emphasises humanhood in relation to Jesus, a person can overcome all sorts of human-made boundaries, including the sexual, racial and class-oriented boundaries through the mediation of Jesus. This further means that the all-inclusive mission of Jesus foregrounds a new criterion for ‘humanhood’ in the Johannine community context. The article concludes by stating that the Johannine understanding of humanhood can be considered as a paradigm in the contemporary global scenario. Contribution: This article contributes to the reader a wider hermeneutical framework and a new way forward in interpreting the gospel according to John by taking into consideration the humanhood aspects. As a theological and contextual interpretation of the Fourth Gospel, the article fits well within the scope of HTS Teologiese Studies/Theological Studies.

The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research results to individual patients. An exploratory pharmacogenetic analysis was conducted in the international ovarian cancer phase III trial, AGO-OVAR 16, which found that patients with clinically important germ-line BRCA1/2 mutations had improved progression-free survival prognosis. Mechanisms to communicate BRCA results were evaluated, because these findings may be beneficial to patients and their families. Communicating individual BRCA results was not anticipated during clinical trial design. Consequently, options were not available for patients to indicate their preference for receiving their individual results when they signed pharmacogenetic informed consent. Differences in local requirements, clinical practice, and opinion regarding the ethical aspects of how to convey genetic results to patients are all potential barriers to returning individual BRCA results to patients. Communicating the aggregate BRCA result from this study provided clinical investigators with a mechanism to disseminate the overall study finding to patients while taking individual circumstances, local guidelines and clinical practice into account. This study illustrates the importance of increasing the clarity and scope of informed consent and the need for patient engagement to ensure clinical trial participants can indicate their preference regarding receipt of potentially important individual pharmacogenetic results. This study was registered in the NCT Clinical Trial Registry under NCT00866697 on March 19, 2009, following approval from participating ethics committees.

Este artigo apresenta um mapeamento sobre estágios e variações em formatos e conteúdos de websites jornalísticos em interfaces móveis. Examinou-se estruturas e modelos de navegação, bem como design, linguagem e relação espacial, do ponto de vista da experiência do usuário, em 10 home pages de jornais impressos brasileiros publicados em versões para smartphones, entre novembro de 2014 e março de 2015. A partir de noções de experiência, percepção e affordances em tempos de convergência midiática, combinou-se recursos metodológicos qualiquantitativos, envolvendo testes humanos e de máquina. Uma das principais conclusões é que os veículos jornalísticos negligenciam, em seus formatos e conteúdos móveis, recomendações internacionais de melhores práticas para a interação de usuários.

This article re-reads John 17:1–26 with a focus on the theme of oneness within the micronarrative. A multilayered and polyvalent analysis of the text reveals that the theme of oneness holds the prayer together to suggest a new way forward for the Johannine community. The vision and the missio-praxis expressed in the prayer align the thought patterns of Jesus, the narrator, and the community of John. The interactions and the resultant wider perichōrētic relationships between Father and Jesus, Jesus and believers, Father and believers, believer(s) and believer(s), Father–Jesus–believers and Paraklētos and Father–Son– Paraklētos –believers and the World exist as a paradigm for today’s ecclesiastical bodies and theological institutions and organisations for wider ecumenism and dialogue. Contribution: This article discusses the theme of oneness in John 17:1–26 as a paradigm for wider ecumenism and dialogue. As HTS Teologiese Studies/Theological Studies emphasises biblical, ecumenical and dialogical engagements in theological discussions, this article fits well within the scope of the journal.

The story of the man born blind is constructed within a grand irony of ability and disability. The Johannine narrator develops the characterisation of the man born blind as a progressive, seeing and missional personality, whereas all others in the story appear as people without proper understanding and vision and those with lower perspectives. Although the world conceived the man as a sinner, Jesus understands him as a means for divine glorification; though the Jews are widely considered able people in the socioreligious terms, Jesus considers them as sinful. The article argues that people can overcome their physical disabilities with the help of spiritual foresight and mental stability; people's physical abilities are not guarantees for their wholistic stability. In that sense, John 9:1-41 can be considered a paradigmatic narrative which demonstrates the experiences of the disabled and marginal sections of the 1st-century CE context. CONTRIBUTION: This article presents the irony of ability and disability within John 9:1-41 and suggests a new way forward in interpreting the fourth gospel by taking into consideration the existential struggles of people with disabilities. As a theological interpretation of the fourth gospel, this article fits well within the scope of HTS Theological Studies.

This article re-reads John 20:1-29 to foreground the normal, the post-normal and the new normal realities within the Johannine resurrection narrative. The narrator of John demonstrates the normal situational aspects by taking into consideration the setting, characterisation, thematic development, point of view and plot development of the story in closer relationship with the temporal and spatial mechanisms. The ordinary, local and existent realities are expressed to reveal the colourless human experiences in relation to the divine aspects within the narrative framework. The resurrection of Jesus introduces a post-normal situation within the Sitz im Leben Jesu and the Sitz im Leben Kirche. The post-normal situation was introduced by placing the story of Lazarus at a strategic place (Jn 11:1-45) and thereafter by unfolding the essentials such as speed, scope, scale and spontaneity. The unfolding of the divine within the existential human realities created a post-normal situation where the Johannine community had to undergo expulsion and persecution from the side of the dominant structures. The narrator gives the reader a hope about a new normal situation above and beyond the existent struggles of the Johannine community. CONTRIBUTION: This article presents a new perspective concerning the normal, the post-normal and the new normal realities and dynamism within John 20:1-29 and suggests a new way forward in interpreting the Fourth Gospel by taking into consideration the existential aspects of the COVID-19 and Omicron pandemic situations. As a contextual and theological interpretation of the Fourth Gospel, this article fits well within the scope of HTS Teologiese Studies/Theological Studies.

As we combat the COVID-19 pandemic, both the prescription of antimicrobials and the use of biocidal agents have increased in many countries. Although these measures can be expected to benefit existing people by, to some extent, mitigating the pandemic's effects, they may threaten long-term well-being of existing and future people, where they contribute to the problem of antimicrobial resistance (AMR). A trade-off dilemma thus presents itself: combat COVID-19 using these measures, or stop using them in order to protect against AMR. Currently, I argue, we are choosing to continue with these measures, and thus to prioritize combatting COVID-19, without adequate ethical reflection on the AMR-associated costs of these measures. I discuss the magnitude of the possible costs and benefits involved in making the trade-off in favour of COVID-19, and their distribution. I highlight two salient aspects of distribution that can help determine whether combatting COVID-19 whilst exacerbating AMR produces justly distributed costs and benefits: distribution between current and future populations, and distribution between existing geographical populations. Adopting this account, I argue that based on the magnitude and distribution of costs and benefits of combatting COVID-19, we have good reason to rethink this trade-off, and instead consider prioritizing protecting current and future people against AMR, but jettisoning measures against COVID-19 that also exacerbate AMR.

This article is an attempt to explore the theme of 'humanhood' in the Fourth Gospel. The most important questions to be posed at the outset are the following: who is the model human presented in the gospel as per the Johannine community standards? How can a person acquire humanhood status according to the Johannine community? The divine and human interaction in the life and ministry of Jesus dynamically introduces the life ethics and mission aspects of the Johannine community. According to the Johannine community standards, people can achieve 'humanhood' status exclusively in relation to Jesus. As the community of John emphasises humanhood in relation to Jesus, a person can overcome all sorts of human-made boundaries, including the sexual, racial and class-oriented boundaries through the mediation of Jesus. This further means that the all-inclusive mission of Jesus foregrounds a new criterion for 'humanhood' in the Johannine community context. The article concludes by stating that the Johannine understanding of humanhood can be considered as a paradigm in the contemporary global scenario.CONTRIBUTION: This article contributes to the reader a wider hermeneutical framework and a new way forward in interpreting the gospel according to John by taking into consideration the humanhood aspects. As a theological and contextual interpretation of the Fourth Gospel, the article fits well within the scope of HTS Teologiese Studies/Theological Studies.

The Coronavirus Disease 2019 pandemic situation persuades a reader of the Fourth Gospel to interpret the Scripture in new lights. In the contemporary context, the gospel of John has the potential to attune the attention of the reader towards the existential struggles of the people with myriad interpretative possibilities. The Jews often twinned sinfulness and sickness together, and in that light, they considered Jesus as a social sinner and his followers as a diseased community. The Johannine narrator realigns the struggles of the Sitz im Leben Kirche dynamically within the Sitz im Leben Jesu to present his defensive rhetoric. The Johannine community was composed of those who suffered quarantine, social isolation, sicknesses, resource deficiencies and continuous cleansing processes in the socio-religious and politico-cultural setting of their life. Jesus as the creator of the universe and the giver of life provides them hope in the midst of suffering and liberates them from the clutches of dehumanisation and marginalisation. A realignment of the Sitz im Leben COVID-19 within the framework of the Sitz im Leben Jesu/Sitz im Leben Kirche would guide us during the difficult times.Contribution: This article contributes to the reader a wider hermeneutical framework and a new way forward in interpreting the Fourth Gospel by taking into consideration the ongoing struggle of humanity across the globe during the COVID-19 pandemic situation. As a narrative, contextual and theological interpretation of the Fourth Gospel, the current article fits well within the scope of HTS Teologiese Studies/Theological Studies.

Over the last decade, iterated learning studies have provided compelling evidence for the claim that linguistic structure can emerge from non‐structured input, through the process of transmission. However, it is unclear whether individuals differ in their tendency to add structure, an issue with implications for understanding who are the agents of change. Here, we identify and test two contrasting predictions: The first sees learning as a pre‐requisite for structure addition, and predicts a positive correlation between learning accuracy and structure addition, whereas the second maintains that it is those learners who struggle with learning and reproducing their input who add structure to it. This prediction is hard to test in standard iterated learning paradigms since each learner is exposed to a different input, and since structure and accuracy are computed using the same test items. Here, we test these contrasting predictions in two experiments using a one‐generation artificial language learning paradigm designed to provide independent measures of learning accuracy and structure addition. Adults (N = 48 in each study) were exposed to a semi‐regular language (with probabilistic structure) and had to learn it: Learning was assessed using seen items, whereas structure addition was calculated over unseen items. In both studies, we find a strong positive correlation between individuals' ability to learn the language and their tendency to add structure to it: Better learners also produced more structured languages. These findings suggest a strong link between learning and generalization. We discuss the implications of these findings for iterated language models and theories of language change more generally.

Traditionally, industrial robots have needed complete segregation from people in manufacturing environments to mitigate the significant risk of injury posed by their high operational speeds and heavy payloads. However, advances in technology now not only enable the application of smaller force-limited robotics for lighter industrial tasks but also wider collaborative deployment of large-scale robots. Such applications will be critical to future manufacturing but present a design and integration challenge as we do not yet know how closer proximity and interactions will impact on workers’ psychological safety and well-being. There is a need to define new ethical and safety standards for putting people and robots together in manufacturing, but to do this we need empirical data to identify requirements. This chapter provides a summary of the current state, explaining why the success of augmenting human–robot collaboration in manufacturing relies on better consideration of human requirements, and describing current research work in the European A4BLUE project to identify this knowledge. Initial findings confirm that ethical and psychological requirements that may be crucial to industrial human–robot applications are not yet being addressed in safety standards or by the manufacturing sector.

Thomas appears four times within the narrative framework of the Fourth Gospel. His presence in the Gospel introduces some of the strategic transitions within the macro-narrative structure. The following are some of the crucial moments that are introduced through the entry of Thomas: firstly, Thomas' character is brought to the foreground towards the end of Jesus' public ministry, where a transition is underway through Lazarus' death and raising to Jesus' death and resurrection ; secondly, he appears as a significant interlocutor engaged in dialogue so that Jesus' identity as 'the way, the truth, and the life' may be revealed to the disciples during his private ministry ; thirdly, Thomas' character appears towards the climax of the Book of Glory as he is instrumental in revealing the identity of Jesus as 'Lord' and 'God' ; and fourthly, he appears as one of the seven disciples during the post-resurrection context in Galilee. The unique placement of Thomas communicates something significant about the character and his development within the narrative.