Thomas Liu

Transcutaneous auricular vagus nerve stimulation, a non-invasive alternative to vagus nerve stimulation with implantable devices, has shown promise in treating disorders such as depression, migraine, and insomnia. Studies of these disorders with resting-state functional magnetic resonance imaging have found sustained changes in resting-state functional connectivity in patients treated with low frequency taVNS. A recent study has reported reductions in pain scores in patients with rheumatoid arthritis after a 12-week treatment of high-frequency sub-threshold taVNS. However, no studies to date have examined the effects of high-frequency sub-threshold taVNS on rsFC. The objective of this study was to determine whether high-frequency sub-threshold taVNS induces changes in rsFC using seed regions from the cingulate cortex and insula, brain regions that play a key role in interoception and processing of pain. With a single-blind placebo-controlled repeated measures experimental design, rsfMRI scans were acquired before and after 15 min of either sub-threshold taVNS treatment or a sham control. Significant taVNS-related changes in functional connections to the cingulate cortex were detected between the anterior cingulate cortex and right superior temporal gyrus and between the midcingulate cortex and right inferior parietal lobule. In addition, significant changes in functional connections to the insula were detected between the posterior insula and right precuneus and between the anterior insula and right cuneus gyrus. These results suggest that high-frequency sub-threshold taVNS can lead to sustained effects on the rsFC of brain regions involved in interoception and processing of pain in a cohort of healthy subjects. This study lays the foundation for future rsfMRI studies of high-frequency sub-threshold taVNS in clinical populations.

BABAR, the detector for the SLAC PEP-II asymmetric e+e- B Factory operating at the γ resonance, was designed to allow comprehensive studies of CP-violation in B-meson decays. Charged particle tracks are measured in a multi-layer silicon vertex tracker surrounded by a cylindrical wire drift chamber. Electromagnetic showers from electrons and photons are detected in an array of CsI crystals located just inside the solenoidal coil of a superconducting magnet. Muons and neutral hadrons are identified by arrays of resistive plate chambers inserted into gaps in the steel flux return of the magnet. Charged hadrons are identified by dE/dx measurements in the tracking detectors and by a ring-imaging Cherenkov detector surrounding the drift chamber. The trigger, data acquisition and data-monitoring systems, VME- and network-based, are controlled by custom-designed online software. Details of the layout and performance of the detector components and their associated electronics and software are presented. © 2002 Elsevier Science B.V. All rights reserved.

© 2015 the American Physiological Society. The early sequence of events leading to the development of the acute respiratory distress syndrome in patients with sepsis remains inadequately understood. The purpose of this study was to identify changes in gene expression early in the course of illness, when mechanisms of injury may provide the most relevant treatment and prognostic targets. We collected whole blood RNA in critically ill patients admitted from the Emergency Department to the intensive care unit within 24 h of admission at a tertiary care center. Whole genome expression was compared in patients with sepsis and ARDS to patients with sepsis alone. We selected genes with >1 log2 fold change and false discovery rate <0.25, determined their significance in the literature, and performed pathway analysis. Several genes were upregulated in 29 patients with sepsis with ARDS compared with 28 patients with sepsis alone. The most differentially expressed genes included key mediators of the initial neutrophil response to infection: olfactomedin 4, lipocalin 2, CD24, and bactericidal/permeability-increasing protein. These gene expression differences withstood adjustment for age, sex, study batch, white blood cell count, and presence of pneumonia or aspiration. Pathway analysis demonstrated overrepresentation of genes involved in known respiratory and infection pathways. These data indicate that several neutrophil-related pathways may be involved in the early pathogenesis of sepsis-related ARDS. In addition, identifiable gene expression differences occurring early in the course of sepsis-related ARDS may further elucidate understanding of the neutrophil-related mechanisms in progression to ARDS.

In two experiments, subjects’ task was to decide whether a binocularly viewed target word was evaluatively good (e.g., fame, comedy, rescue) or bad (e.g., stress, detest, malaria) in meaning. Just prior to this target word, a priming word was presented to the nondominant eye, and masked by an immediately following presentation of a letter—fragment pattern to the dominant eye. (Masking effectiveness was demonstrated by subjects’ failure to discriminate the left vs. right position of a test series of words.) In Experiment 1, which used evaluatively positive or negative words as priming stimuli, judgment latency for the evaluative decision task was facilitated by primes that agreed in evaluation with targets, and was retarded by primes that disagreed in evaluation with targets. This result demonstrated that the evaluative meaning of priming stimuli was processed under conditions that prevented subjects from detecting their presence. Primes in Experiment 2 were 2-word strings for which the evaluative meaning of individual words was orthogonal to the evaluative sentence meaning (e.g., the two evaluatively negative words, "enemy fails,“ make up an evaluatively positive sentence). Results of Experiment 2 indicated that masked priming effects were influenced by the evaluative meanings of individual words, but not by their sentence meanings. This result supported the conclusion that the processing of undetected, dichoptically masked words is limited to analyses that are not powerful enough to extract sentence meanings.