•  2
    The Kanchenjunga Conservation Area Project provides a remarkable example of a gender-sensitive nature conservation project. The KCAP is an Integrated Conservation and Development Project in the mountainous area of East Nepal, jointly managed by the WWF Nepal Program and the Nepalese Department of National Parks and Wildlife Conservation. The project includes a specific women's-development approach. It not only aims at direct integration of women into nature conservation, but also applies a broad…Read more
  • Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy
    with G. U. Höglinger, N. M. Melhem, D. W. Dickson, P. M. A. Sleiman, L. S. Wang, L. Klei, R. Rademakers, R. De Silva, I. Litvan, J. C. de RileyVan Swieten, P. Heutink, Z. K. Wszolek, R. J. Uitti, J. Vandrovcova, H. I. Hurtig, R. G. Gross, W. Maetzler, S. Goldwurm, E. Tolosa, B. Borroni, P. Pastor, L. B. Cantwell, M. R. Han, A. Dillman, M. P. Van Der Brug, Gibbs Jr, M. R. Cookson, D. G. Hernandez, A. B. Singleton, M. J. Farrer, C. E. Yu, L. I. Golbe, T. Revesz, J. Hardy, A. J. Lees, B. Devlin, H. Hakonarson, G. D. Schellenberg, R. L. Albin, E. Alonso, A. Antonini, M. Apfelbacher, S. E. Arnold, J. Avila, T. G. Beach, S. Beecher, D. Berg, T. D. Bird, N. Bogdanovic, A. J. W. Boon, Y. Bordelon, A. Brice, H. Budka, M. Canesi, W. Z. Chiu, R. Cilia, C. Colosimo, P. P. De Deyn, J. G. De Yebenes, L. D. Kaat, R. Duara, A. Durr, S. Engelborghs, G. Fabbrini, N. A. Finch, R. Flook, M. P. Frosch, C. Gaig, D. R. Galasko, T. Gasser, M. Gearing, E. T. Geller, B. Ghetti, N. R. Graff-Radford, M. Grossman, L. N. da HallHazrati, M. Höllerhage, J. Jankovic, J. L. Juncos, and Karydas
    Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in…Read more
  • © 2015 Amini and Müller. The group I intron ribozyme from Tetrahymena was recently reengineered into a trans-splicing variant that is able to remove 100- nt introns from pre-mRNA, analogous to the spliceosome. These spliceozymes were improved in this study by 10 rounds of evolution in Escherichia coli cells. One clone with increased activity in E. coli cells was analyzed in detail. Three of its 10 necessary mutations extended the substrate binding duplexes, which led to increased product formati…Read more
  • Group I introns are ribozymes that excise themselves from RNA primary transcripts by catalyzing two successive transesterification reactions. These cis-splicing ribozymes can be converted into trans-splicing ribozymes, which can modify the sequence of a separate substrate RNA, both in vitro and in vivo. Previous work on trans-splicing ribozymes has mostly focused on the 16S rRNA group I intron ribozyme from Tetrahymena thermophila. Here, we test the trans-splicing potential of the tRNAIle group …Read more
  • Understanding the evolution of functional RNA molecules is important for our molecular understanding of biology. Here we tested experimentally how two evolutionary parameters, selection pressure and recombination, influenced the evolution of an evolvingRNApopulation. This was done using four parallel evolution experiments that employed low or gradually increasing selection pressure, and recombination events either at the end or dispersed throughout the evolution. As model system, a trans-splicin…Read more
  •  1
    Access to livelihood assets: insights from South Asia on how institutions work
    with B. Shahbaz, C. P. Vinod, U. Geiser, T. Sadaf, and L. Schärer
    In , . 2010.
    The present contribution is an attempt to understand the conditions that impede some households and social groups in securing a decent livelihood by drawing on ‘purported’ facilitating institutions. It is generally agreed that access to livelihood assets is negotiated through institutions. However, the way in which these institutions operate in everyday practice and in specific contexts is less well understood. The four case studies presented here there- fore analyse how customary norms and stat…Read more
  •  4
    Rawls global
    Polis 2. 2002.
    El autor recoge el tema de la justicia social, a partir de las propuestas de John Rawls, para preguntarse por las consecuencias de la globalización respecto del tema de la justicia. Recoge la pregunta fundamental de Rawls sobre la posibilidad de encontrar principios de justicia universalmente obligatorios; pero releva que su límite son las sociedades democráticas occidentales modernas, y que otros órdenes sociales no encajan, por lo que Rawls no ofrece una teoría universal. Analiza luego otros a…Read more
  • Objectivity and way of life, Kant philosophy of culture
    Philosophisches Jahrbuch 98 (1): 62-77. 1991.
  •  3
    The present case study of the Kangchenjunga Conservation Area Project, located in the north-eastern corner of Nepal, empirically investigates successes in and obstacles to addressing biodiversity conservation priorities at the same time as local inhabitants’ livelihood needs. The research results indicate an improvement in forest conditions and a perceptible growth of the wildlife population – judging from the increase in crop and livestock depredations – as well as an enhancement of local peopl…Read more
  •  1
    Wie ist ästhetisches Argumentieren moglich?
    Philosophisches Jahrbuch 96 (1): 151-156. 1989.
  • Objektivität und Fiktionalität. Einige Überlegungen zu Kants Kritik der ästhetischen Urteilskraft
    Société Française de Philosophie, Bulletin 77 (2): 203. 1986.
  • Disfiguring Aphrodite-Philosophy of modern art
    Philosophisches Jahrbuch 108 (1): 133-148. 2001.