Vivek Sharma

This article is a step towards a rethinking of the emergence of the modern state in Europe. Traditionally, war has been viewed as the central mechanism of state formation. This approach claims that war caused the emergence of the modern state in two significant ways: 1) by consolidating the politically fragmented world of the middle ages through conquest; and 2) through the pressure of competition in a Darwinian international system, which forced the polities of Europe to create the bureaucratic structures fundamental to the authority of the modern state. This article seeks to undermine the first of these mechanisms by showing that the territorial consolidation of Europe was a logical result of dynastic lordship. I seek to show that the consolidation of territory and authority into fewer and fewer hands was a direct consequence of dynastic successional practices and therefore that the emphasis on coercion in European political development has been overplayed.

Transcutaneous auricular vagus nerve stimulation, a non-invasive alternative to vagus nerve stimulation with implantable devices, has shown promise in treating disorders such as depression, migraine, and insomnia. Studies of these disorders with resting-state functional magnetic resonance imaging have found sustained changes in resting-state functional connectivity in patients treated with low frequency taVNS. A recent study has reported reductions in pain scores in patients with rheumatoid arthritis after a 12-week treatment of high-frequency sub-threshold taVNS. However, no studies to date have examined the effects of high-frequency sub-threshold taVNS on rsFC. The objective of this study was to determine whether high-frequency sub-threshold taVNS induces changes in rsFC using seed regions from the cingulate cortex and insula, brain regions that play a key role in interoception and processing of pain. With a single-blind placebo-controlled repeated measures experimental design, rsfMRI scans were acquired before and after 15 min of either sub-threshold taVNS treatment or a sham control. Significant taVNS-related changes in functional connections to the cingulate cortex were detected between the anterior cingulate cortex and right superior temporal gyrus and between the midcingulate cortex and right inferior parietal lobule. In addition, significant changes in functional connections to the insula were detected between the posterior insula and right precuneus and between the anterior insula and right cuneus gyrus. These results suggest that high-frequency sub-threshold taVNS can lead to sustained effects on the rsFC of brain regions involved in interoception and processing of pain in a cohort of healthy subjects. This study lays the foundation for future rsfMRI studies of high-frequency sub-threshold taVNS in clinical populations.