Wei Zhu

The PREPARED Code is a risk-based, values-driven framework that integrates research ethics and research integrity and is designed for a global audience. Developed over two years, this ambitious initiative required a collaborative, multidisciplinary effort led by an international team. The PREPARED team employed a range of methods to develop the code, including literature searches, scoping reviews, empirical studies, targeted consultations, ethical and legal analyses, and public consultation. This chapter explores the processes and methods used to develop the PREPARED Code, highlighting how real-world challenges in research ethics and research integrity during crises were identified, analysed and validated by stakeholders. It describes how these challenges were aligned with universally recognised moral values and grouped as risks, and how the risks were transformed into a clear, focused and jargon-free code of conduct. It also details the final stages of development, which involved iterative refinement of the code from Version 1 to Version 13, through extensive consultation and review.

Lineage progression and diversification is regulated by the coordinated action of unique sets of transcription factors. Oligodendrocytes and astrocytes comprise the glial sub-lineages in the CNS, and the manner in which their associated regulatory factors orchestrate lineage diversification during development and disease remains an open question. Sox10 and NFIA are key transcriptional regulators of gliogenesis associated with OL and AS. We found that NFIA inhibited Sox10 induction of OL differentiation through direct association and antagonism of its function. Conversely, we found that Sox10 antagonized NFIA function and suppressed AS differentiation in mouse and chick systems. Using this developmental paradigm as a model for glioma, we found that this relationship similarly regulated the generation of glioma subtypes. Our results describe the antagonistic relationship between Sox10 and NFIA that regulates the balance of OL and AS fate during development and demonstrate for the first time, to the best of our knowledge, that the transcriptional processes governing glial sub-lineage diversification oversee the generation of glioma subtypes.

“Suspension of judgment” is an ambiguous term that may refer either to a doxastic state (“suspended judgment”) or to a doxastic action (“suspending judgment”). Based on a simple non-belief account, this paper presents a formal study of both aspects of suspension. We first introduce the notion of a suspension set (a set of non-beliefs) and determine its logical structure. Then we present the classical AGM operations of belief revision and belief contraction and give characterizations of them that refer to suspension sets rather than belief sets. Finally, we study the suspension operation, a symmetric cousin of belief contraction, and characterize it both in terms of belief sets and in terms of suspension sets. Belief contraction and belief suspension thereby get reinterpreted as two different forms of the expansion of suspension sets. The project is interesting because in contrast to belief revision and belief contraction, the suspension operation is symmetric with respect to negation: suspending judgment on _A_ is the same as suspending judgment on $$\lnot A$$. Most of our results are premised on an assumption of modesty: For every person with consistent beliefs, there is always at least one proposition on which she suspends judgment.

In this paper, a graph-based nonlocal total variation method is proposed for unsupervised classification of hyperspectral images. The variational problem is solved by the primal-dual hybrid gradient algorithm. By squaring the labeling function and using a stable simplex clustering routine, an unsupervised clustering method with random initialization can be implemented. The effectiveness of this proposed algorithm is illustrated on both synthetic and real-world HSI, and numerical results show that the proposed algorithm outperforms other standard unsupervised clustering methods such as spherical K-means, nonnegative matrix factorization, and the graph-based Merriman-Bence-Osher scheme.

In the medical practice in China, giving and taking “red envelopes” is a common phenomenon although few openly admit it. This paper, based on our empirical study including data collected from interviews and questionnaires with medical professionals and patients, attempts to explore why “red envelopes” have become a serious problem in the physician-patient relationship and how the situation can be improved. Previous studies show that scholars tend to correlate the spread of “red envelopes” in health care sector to the commercialization trend, the general erosion of traditional values, and the lowering of the moral level in the medical field. However, in this paper, the authors argue that medical professionals’ choice of taking “red envelopes” is actually more a way to compensate for their problematic self-image and marred dignity in real practice. Medical professionals in China as a whole are in an embarrassing situation where the work pressure and income, and the sense of pride that used to be part of their profession are not comparable to each other. Under this circumstance, we believe that the effective way to deal with the “red envelopes” issue does not lie solely in introducing more stringent regulations or granting medical professionals higher payments, but rather in protecting and enhancing the professional dignity of all those working in healthcare. And on top of that, there must also be effort to cultivate a more favorable moral environment.

Hintikka’s game theoretical approach to semantics has been successfully applied also to some non-classical logics. A recent example is Başkent (A game theoretical semantics for logics of nonsense, 2020. arXiv:2009.10878), where a game theoretical semantics based on three players and the notion of dominant winning strategy is devised to fit both Bochvar and Halldén’s logics of nonsense, which represent two basic systems of the family of weak Kleene logics. In this paper, we present and discuss a new game theoretic semantics for Bochvar and Halldén’s logics, GTS-2, and show how it generalizes to a broader family of logics of variable inclusions.