Xiaowei Wang

Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In our previous investigations, we developed a miRNA domain-specific application ontology, Ontology for MIcroRNA Target (OMIT), to provide the community with common data elements and data exchange standards in the miRNA research. This paper describes (1) our continuing efforts in the OMIT ontology development and (2) the application of the OMIT to enable a semantic approach for knowledge capture of miRNA-target interactions.

This article discusses a Confucian notion of cosmological life and its eco-philosophical implication. In contrast to the Kantian notion of the man who has exclusive moral worth, existing as the ultimate value-conferrer among beings, Confucian cosmological man understands his/her selfness through the lens of sacred unity with other beings. The modern ecological disaster is arguably caused by the reluctance to recognize the inherent value of nature, which is due to the anthropocentrism partly introduced by the enlightenment notion of humanity. The Confucian cosmological person worships the ultimate value of the cosmos as a unity of heaven, humans, and earth, and in so doing delivers genuine care for the environment, not for the sake of its instrumental but for its inherent value.

In this paper, I discussed the possibility to argue for a human right to internet access in Confucian society. I argued firstly that Confucianism could properly accommodate the concept of human rights, even though it does not have an explicit term for it. Secondly, Confucian concept of min xin, as a similar concept of democracy with differences, is used in Confucianism as a normative concept to lay the foundation of the state and legitimatize the governance. Last but not least, I argued that the roles that min xin are supposed to play in reality are never fully carried out due to the specific hierarchical information structure of Confucian society. I proposed that with internet, the concept of min xin would have to be able to play its roles properly. As such, the arguments that disregard internet access by referting to the protection of the Confucian values might not stand.

A nonlinear coupled wing model subject to unknown external disturbances is proposed in this paper. Since the model is modeled by partial differential equations, the traditional control design scheme based on the ordinary differential equation model is not applicable, and the control law design becomes very complex. In this paper, a new antidisturbance boundary control scheme based on a finite time convergent disturbance observer is proposed. The control laws are designed based on the new disturbance observers to make the external disturbance errors converge to zero in a finite time and ensure the uniformly bounded stability of the controlled system. Finally, the effectiveness of the controllers and the finite-time convergence of disturbance errors are verified by the simulation and comparison.

Physical contact between organelles are widespread, in part to facilitate the shuttling of protein and lipid cargoes for cellular homeostasis. How do protein‐protein and protein‐lipid interactions shape organelle subdomains that constitute contact sites? The endoplasmic reticulum (ER) forms extensive contacts with multiple organelles, including lipid droplets (LDs) that are central to cellular fat storage and mobilization. Here, we focus on ER‐LD contacts that are highlighted by the conserved protein seipin, which promotes LD biogenesis and expansion. Seipin is enriched in ER tubules that form cage‐like structures around a subset of LDs. Such enrichment is strongly dependent on polyunsaturated and cyclopropane fatty acids. Based on these findings, we speculate on molecular events that lead to the formation of seipin‐positive peri‐LD cages in which protein movement is restricted. We hypothesize that asymmetric distribution of specific phospholipids distinguishes cage membrane tubules from the bulk ER.