Yan Zhou

ObjectiveThe information age has transformed technologies across disciplines. Generative artificial intelligence (GenAI), as an emerging technology, has integrated into scientific research. Recent studies identify GenAI-related scientific research integrity concerns. Using Complex Adaptive Systems (CAS) theory, this research examines risk factors and preventive measures for each agent within the scientific research integrity management system during GenAI adoption, providing new perspectives for integrity management.MethodThis study applies CAS theory to analyze the scientific research integrity management system, identifying four core micro-level agents: researchers, research subjects, scientific research administrators, and academic publishing institutions. It examines macro-system complexity, agent adaptability, and the impact of agent interactions on the overall system. This framework enables analysis of GenAI’s effects on the research integrity management system.ResultsThe scientific research integrity management system exhibits structural, hierarchical, and multidimensional complexities, with internal circulation of policy, funding, and information elements. In response to GenAI integration, four micro-level agents—researchers, research subjects, scientific research administrators, and academic publishing institutions—adapt their behaviors to systemic changes. Through these interactions, behavioral outcomes emerge at the macro level, driving evolution of the research integrity management system.ConclusionsRisks of scientific misconduct permeate the entire research process and require urgent governance. This study recommends that scientific research administrators promptly define applicable boundaries for GenAI in research to guide researchers. Concurrently, they should collaborate with relevant departments to establish regulatory frameworks addressing potential GenAI-related misconduct. Academic publishing institutions must assume quality assurance responsibilities by strengthening review and disclosure protocols. Furthermore, research integrity considerations should be systematically integrated into GenAI’s technological development and refinement.Highlights● Develops an analytical framework grounded in Complex Adaptive Systems (CAS) theory to map evolving interactions among researchers, research subjects, scientific research administrators, and academic publishing institutions within GenAI-integrated research ecosystems. ● Identifies self-reinforcing dynamics between GenAI adoption and integrity governance, wherein adaptive rule adjustments by agents reshape system-wide integrity thresholds. ● Proposes adaptive governance mechanisms that balance innovation safeguards with integrity guardrails, emphasizing context-sensitive policy calibration over universal solutions.

Purpose: This study aimed to explore the relationship between mathematic achievement and programming self-efficacy, and adopt a mediation model to verify the mediating role of creativity on the relationship between mathematic achievement and programming self-efficacy.Methods: A total of 950 upper-secondary school students were surveyed using their math test scores, the Kirton Adaption-Innovation and the Programmed Self-Efficacy Scale. SPSS-26 was used for descriptive statistical analysis and correlation analysis of related variables. The PROCESS plugin was used to test the mediating effect of creativity.Results: Mathematic achievement has a positive effect on programming self-efficacy, mathematic achievement is positively related to creativity, and creativity also has a positive influence on programming self-efficacy. Creativity has a mediating effect on the relationship between mathematic achievement and programming self-efficacy.Conclusion: The results revealed that mathematic achievement affected programming self-efficacy directly and also indirectly through creativity. This provided certain ideas for the development of programming education for teenagers. Since students’ mathematics learning and creativity are related to programming learning, it is necessary to pay attention to the integration of the disciplines of programming education and mathematics. Further, the cultivation of innovative thinking is also critical to facilitate programming learning.

According to the causal account of harming, an event harms a person if and only if it causes the person to be worse off. This view has emerged as a popular alternative to the more traditional view, according to which an event harms a person if and only if the person would have been better off had the event not occurred. In this paper, my primary aim is to motivate and defend a certain variant of the causal account of harming. Moreover, I also situate this variant within recent attempts to provide a unified account of harm.

The impact of environmental, social, and governance (ESG) scores on firm performance (FP) has long been a focus of theoretical and practical debate. We address this controversy by focusing on Chinese heavy-polluting firms. Drawing on agent theory and threat rigidity theory, we propose that top management team (TMT) stability and external pressures (government environmental punishment and negative media coverage) jointly affect the relationship between ESG scores and FP. Analyzing data from 1392 A-share listed heavy-polluting firms in China from 2007 to 2022, our findings reveal that heavy-polluting firms with higher ESG scores tend to exhibit poorer FP. Notably, this relationship varies based on TMT stability and external pressures. Specifically, TMT stability weakens the negative effect of ESG scores on FP. When external pressures are high, TMT stability negatively impacts the relationship between ESG scores and FP. Conversely, TMT stability positively affects this relationship when external pressures are low. This study identifies the specific conditions in which TMT stability affects from the perspective of agency theory and threat rigidity theory, and provides a new insight for firms and governments in emerging economies to promote ESG practices effectively.

This paper engages with the longstanding debate over whether being exposed to a risk of harm amounts to harm itself (what I call ‘risk-harm’). The dominant view has been that those exposed to risks of harm do not suffer harm. In this paper, I defend the widely unpopular subjectivist account of risk-harm – according to which those exposed to unwanted risks of harm can suffer harm – against prominent objections that have been levied against it. The first section sets out to renew and strengthen the appeal of the account in light of recent developments in the surrounding literature. The second section defends the account against arguably its most formidable objection, namely the claim that there is no such thing as risk-harm. The third section wraps up by parrying some prominent general objections, which highlight potentially undesirable upshots to accepting the existence of risk-harm.

Background: Endothelins are paracrine peptides with growth-promoting and vasoactive functions for a variety of cell types. Elevated activation of the endothelin signaling pathway induces cell proliferation and/or survival and is implicated in a variety of malignancies. Increased endothelin 1 was described in solar lentigines in previous reports, raising the possibility that the endothelin pathway may be of significance in keratinocyte proliferation-related disorders. However, detailed investigation on endothelins in skin malignancies is lacking. Objectives: This study aims to survey the expression of endothelins and their receptors in keratinocyte-derived benign and malignant tumors of the skin and to test the effects of endothelin inhibitors on the growth and survival of cultured keratinocytes. Methods: Quantitative polymerase chain reaction was used to measure the level of gene transcription of three endothelins and two endothelin receptors. The genes with significant messenger ribonucleic acid expression abnormalities were confirmed with immunohistochemical analysis to examine expression differences at the protein levels. To analyze the effect of endothelin inhibitors on the keratinocyte growth and survival, keratinocytes were cultured in the presence of various concentrations of endothelin inhibitors and subjected to tetrazolium bromide assay to quantify the cell numbers over time. Results: ET-1 mRNA was found to be significantly up-regulated in seborrheic keratosis and basal cell carcinoma. However, no significant expression increase was found in actinic keratosis, Bowen's disease, or squamous cell carcinoma. Immunohistochemical analysis of ET-1 peptide confirmed increased expression. In cultured keratinocytes, peptide inhibitors of the endothelin pathway resulted in a marked reduction in cell survival. Conclusion: The endothelin signaling pathway, especially ET-1, is activated in basoloid keratinocyte neoplasms of the skin, such as basal cell carcinoma and seborrheic keratosis. Blockade of this pathway can reduce cell survival in vitro. Therefore, endothelin inhibitors potentially offer a novel method for the treatment of some keratinocyte-derived skin tumors.

© 2014 Li et al. Aedes albopictus is a very invasive and aggressive insect vector that causes outbreaks of dengue fever, chikungunya disease, and yellow fever in many countries. Vector ecology and disease epidemiology are strongly affected by environmental changes. Urbanization is a worldwide trend and is one of the most ecologically modifying phenomena. The purpose of this study is to determine how environmental changes due to urbanization affect the ecology of Aedes albopictus. Aquatic habitats and Aedes albopictus larval population surveys were conducted from May to November 2013 in three areas representing rural, suburban, and urban settings in Guangzhou, China. Ae. albopictus adults were collected monthly using BG-Sentinel traps. Ae. albopictus larva and adult life-table experiments were conducted with 20 replicates in each of the three study areas. The urban area had the highest and the rural area had the lowest number of aquatic habitats that tested positive for Ae. albopictus larvae. Densities in the larval stages varied among the areas, but the urban area had almost two-fold higher densities in pupae and three-fold higher in adult populations compared with the suburban and rural areas. Larvae developed faster and the adult emergence rate was higher in the urban area than in suburban and rural areas. The survival time of adult mosquitoes was also longer in the urban area than it was in suburban and rural areas. Study regions, surface area, water depth, water clearance, surface type, and canopy coverage were important factors associated with the presence of Ae. albopictus larvae. Urbanization substantially increased the density, larval development rate, and adult survival time of Ae. albopictus, which in turn potentially increased the vector capacity, and therefore, disease transmissibility. Mosquito ecology and its correlation with dengue virus transmission should be compared in different environmental settings.

Machery et al. presented data suggesting the existence of cross-cultural variation in judgments about the reference of proper names. In this paper, we examine a previously overlooked confound in the subsequent studies that attempt to replicate the results of Machery et al. using East Asian languages. Machery et al. and Sytsma et al. claim that they have successfully replicated the original finding with probes written in Chinese and Japanese, respectively. These studies, however, crucially rely on uses of articleless, ‘bare noun phrases’ in Chinese and Japanese, which according to the linguistic literature are known to be multiply ambiguous. We argue that it becomes questionable whether the extant studies using East Asian languages revealed genuine cross-cultural variation when the probes are reevaluated based on a proper linguistic understanding of Chinese and Japanese bare noun phrases and English definite descriptions. We also present two experiments on native Japanese speakers that controlled the use of ambiguous bare noun phrases, the results of which suggest that the judgments of Japanese speakers concerning the reference of proper names may not diverge from those of English speakers.

Although some cognitive studies provided reasons that children with low socioeconomic status (SES) showed poor mathematical achievements, there was no explicit evidence to directly explain the root of lagged performance in children with low SES. Therefore, the present study explored the differences in neural correlates in the process of symbolic magnitude comparison between children with different SES by the event-related potentials (ERP). A total of 16 second graders from low SES families and 16 from middle/high SES families participated in this study. According to the results of anterior N1 (early attention) and P2 (extraction of numerical meaning) over frontal region, the differences among children with different SES were manifested as differences in general neural activities in terms of attention and top-down cognitive control. In the late stage of cognitive processing, there was no significant difference in the average amplitude of the LPC between the children with different SES, indicating that low SES did not influence the information encoding and memory updating of numerical representation responsible by the parietal lobe. The educational implications of this study were mentioned in the discussion.

The thesis of relation between observation and theory is one of the basic important issues in philosophy of science and scientific epistemology. However, the mechanistic processes of theory- ladenness of observation have rarely been discussed. Current research in cognitive science on thought processes provides powerful analytical tools and empirical support for this problem. In the light of the perception-based knowledge representation of Barsolou, this paper attempts to give a representation-based explanation for theory- laden mechanism in virtue of constraints on production and explanation of representation. If representational mechanism in observation is not an absolutely subjective but a constraint construction, it will give the reliability of observation a rational support.

Organizational sustainability in the form of environmental management and sustainable production is becoming more important for small and medium-sized enterprises throughout the world. This research evaluates the factors affecting the understanding of the CEO's and managers' intention to adopt practices of green supply chain management and clean innovation technology in the manufacturing SMEs of Pakistan. This empirical research identifies key determinants influencing the adoption of GSCM practices. Using structural equation modeling, we selected a sample size of 350 different manufacturing firms in Pakistan. The results of the study revealed that six factors, namely, environmental, government, organization, suppliers, market, and operational factors, significantly influence the intention to adopt GSCM and positively impact sustainable production. The study's findings reveal that market and operational factors are highly significant for adopting GSCM practices at a p-value of 0.05. Environmental and organizational factors are equally significant to adopt GSCM practices at a p-value of 0.10. This research also analyzed CIT as a moderator between environmental, government, organization, customer, supplier, economic, market, and operational factors in the context of Pakistan. Hypotheses H9a, H9b, H9f, and H9g were validated and support the use of CIT to boost enterprise production and consumption. The research findings would help policymakers understand how to implement GSCM practices and guide enterprises to implement GSCM and CIT practices for enhancing enterprise performance and environmental sustainability.

This paper defends what I call the ‘wellbeing conception of harm’, according to which the relevant criterion for determining whether one has suffered harm is whether they have been made worse off in terms of their wellbeing. Firstly, I explain why it is that one might find the wellbeing conception of harm appealing to begin with. Then, I respond to two sets of concerns that have been levied against the wellbeing conception of harm. The first set of concerns relate to the implausible moral/political consequences that would allegedly follow from adopting the wellbeing conception of harm. The second set of concerns challenge the practical significance of adopting the wellbeing conception of harm. I conclude with some remarks on how the wellbeing conception of harm can help to answer, or at least navigate, some controversial issues related to harm.

Online shopping for customized garments has become the fastest-growing field of the Chinese eBusiness market. Most consumers not only limit themselves to buying standardized garments but also want to buy garments customized to their preferences. This phenomenon has pushed the fashion textile and apparel industry to change its supply chain operations to meet the customization demand. Besides, the fashion textile and apparel industry also want to study how different channel factors will affect consumers' perceived value and further influence consumers' purchasing decisions. We initiated this study and empirically tested more than 200 experienced consumers. This study collaborated with a fashion textile and apparel company that aims to implement customized product lines soon. Based on the perceived value theory and risk management theory, we investigated whether product involvement and channel identification on supply chain design will affects potential customized product consumers' purchasing decisions. The findings reveal that channel recognition affects consumer decisions by having a positive impact on their perceived value. The perceived risk and shopping channel involvement of consumers have a negative impact on their perceived values and channel selections. In addition, product involvement has a moderating effect on the relationship between channel's perceived risk, perceived values, and channel selections as well.

Since Oregon implemented its Death with Dignity Act, many additional states have followed suit demonstrating a growing understanding and acceptance of aid in dying processes. Traditionally, the patient has been the one to request and seek this option out. However, as Death with Dignity acts continue to expand, it will impact the role of physicians and bring up questions over whether physicians have the ethical obligation to facilitate a conversation about AID with patients during end of life discussions. Patients have the right to make informed decisions about their health, which implies that physicians have an obligation to discuss with and inform patients of the options that will accomplish the patients’ goals of care. We will argue that physicians have an ethical obligation to inform certain patients about AID during end of life care discussions. We will also address what this obligation encompasses and explore guidelines of when and how these conversations should occur and proceed. Earlier guidelines, presented by various palliative care and ethics experts, for proceeding with such conversations have mostly agreed that the discussion of hospice and end of life care with patients should be initiated early and that the individual goals of a patient during the remaining duration of life should be thoroughly examined before discussion of appropriate options. In discussing AID, physicians should never recommend but inform patients about the basics so that they can make an informed decision. If patients express further interest in AID, the physician should open up the dialogue to address the reasoning behind this decision versus other possible treatments to ensure that patients clearly comprehend the process and implications of their decision. Ultimately, any end of life choice should be made by patients with the full capacity to express what they envision for the remaining duration of life and to comprehend the advantages and disadvantages of all the possible options.

Aiming to realize rapid and efficient three-dimensional identification of substation equipment, this article proposes a new method in which the 3D identification of substation equipment is based on K-nearest neighbor classification of subspace feature vector. First of all, the article uses octree encoding to reduce and denoise the point cloud data obtained by a 3D laser scanner. Secondly, position calibration and size standardization are used for the point cloud after pretreatment. Then, the normalized point cloud is divided into a number of cubes with same size. The cosine of the angle between the positive direction of z axis and a vector from the global centroid of the point cloud to the centroid of each subspace is regarded as the feature of the subspace. All cosines of subspaces constitute the feature of the point cloud. Finally, we classify the subspace feature vector by using the KNN algorithm and improve classification accuracy by using the particle swarm optimization algorithm. The simulation results show that the identification accuracy of the proposed method for unknown substation equipment is about 90% and the proposed method is applicable to low-degree losses. Apparently, this method can accurately identify 3D substation equipment. At the same time, increasing the number of subspaces will improve the accuracy; however, it will increase the recognition time.