•  2
    Molecular architecture of contactin-Associated protein-like 2 and its interaction with contactin 2
    with Z. Lu, Mvvvs Reddy, J. Liu, A. Kalichava, L. Zhang, F. Chen, L. M. F. Holthauzen, M. A. White, S. Seshadrinathan, X. Zhong, G. Ren, and G. Rudenko
    Contactin-Associated protein-like 2 is a large multidomain neuronal adhesion molecule implicated in a number of neurological disorders, including epilepsy, schizophrenia, autism spectrum disorder, intellectual disability, and language delay. We reveal here by electron microscopy that the architecture of CNTNAP2 is composed of a large, medium, and small lobe that flex with respect to each other. Using epitope labeling and fragments, we assign the F58C, L1, and L2 domains to the large lobe, the FB…Read more
  •  2
    Analysis of gene expression patterns in gastric cancer can help to identify a comprehensive panel of gene biomarkers for predicting clinical outcomes and to discover potential new therapeutic targets. Here, a multi-step bioinformatics analytic approach was developed to establish a novel prognostic scoring system for GC. We first identified 276 genes that were robustly differentially expressed between normal and GC tissues, of which, 249 were found to be significantly associated with overall surv…Read more
  •  3
    Nuclear phosphatase PPM1G in cellular survival and neural development
    with W. H. Foster, A. Langenbacher, C. Gao, and J. Chen
    Background: PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage. However, its in vivo function is unknown. Results: Here we show that ppm1g expression is highly enriched in the central nervous system during mouse and zebrafish development. ppm1g-/- mice were embryonic lethal with incomplete penetrance after E12.5. Rostral defects, including neural tube and craniofacial defects were observed in ppm1g-/- embr…Read more
  •  3
    Background: Malaria around the China-Myanmar border is a serious health problem in the countries of South-East Asia. An. minimus is a principle malaria vector with a wide geographic distribution in this area. Malaria is endemic along the boundary between Yunnan province in China and the Kachin State of Myanmar where the local Anopheles community and the malaria transmission vectors have never been clarified. Methods. Adult Anopheles specimens were collected using CDC light traps in four villages…Read more
  •  8
    Strain-induced preferential dissolution at the dislocation emergences in MnS: an atomic scale study
    with Y. T. Zhou, S. J. Zheng, B. Zhang, and X. L. Ma
    Philosophical Magazine 95 (22): 2365-2375. 2015.
  •  9
    Microstructures of a single-crystal nickel-base superalloy after thermo-mechanical fatigue
    with S. X. Li †, L. Zhou, S. H. Ai, F. Liu, H. Zhang, and Z. G. Wang
    Philosophical Magazine 84 (31): 3335-3351. 2004.
  •  12
    Atomic structure of the Fe/Fe3C interface with the Isaichev orientation in pearlite
    with Y. T. Zhou, S. J. Zheng, Y. X. Jiang, T. Z. Zhao, and X. L. Ma
    Philosophical Magazine 1-12. forthcoming.
  •  10
    The evolution of polarization inside ultrathin PbTiO3films: a theoretical study
    with Y. B. Xue, D. Chen, Y. L. Tang, Y. L. Zhu, and X. L. Ma
    Philosophical Magazine 95 (19): 2067-2077. 2015.
  •  8
    Separations by Random Oracles and "Almost" Classes for Generalized Reducibilities
    with W. Merkle
    Mathematical Logic Quarterly 47 (2): 249-270. 2001.
    Let ≤r and ≤sbe two binary relations on 2ℕ which are meant as reducibilities. Let both relations be closed under finite variation and consider the uniform distribution on 2ℕ, which is obtained by choosing elements of 2ℕ by independent tosses of a fair coin.Then we might ask for the probability that the lower ≤r-cone of a randomly chosen set X, that is, the class of all sets A with A ≤rX, differs from the lower ≤s-cone of X. By c osure under finite variation, the Kolmogorov 0-1 aw yields immediat…Read more
  •  10
    Indications of bulk property changes from surface ion implantation
    with B. Yang, N. Can, and P. D. Townsend
    Philosophical Magazine 91 (2): 250-262. 2011.
  •  1
    Visualizing the mechanical activation of Src
    with E. L. Botvinick, Y. Zhao, M. W. Berns, S. Usami, R. Y. Tsien, and S. Chien
    The mechanical environment crucially influences many cell functions 1. However, it remains largely mysterious how mechanical stimuli are transmitted into biochemical signals. Src is known to regulate the integrin-cytoskeleton interaction2, which is essential for the transduction of mechanical stimuli3-5. Using fluorescent resonance energy transfer, here we develop a genetically encoded Src reporter that enables the imaging and quantification of spatio-temporal activation of Src in live cells. We…Read more
  •  1
    Using the ER-fMRI technique, the present study was designed to investigate the neural substrates of language switching among second-language learners. Twelve Chinese college students who were learning English were scanned when they performed language switching tasks. Compared to non-switching conditions, language switching elicited greater activation in the right superior prefrontal cortex, left middle and superior frontal cortex, and right middle cingulum and caudate. When the direction of swit…Read more
  •  3
    Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort
    with Wade Bsc, Vg Valcour, L. Wendelken-Riegelhaupt, P. Esmaeili-Firidouni, sh JoShi, and Pm Thompson
    © 2015 IEEE. Over 50% of HIV+ individuals exhibit neurocognitive impairment and subcortical atrophy, but the pattern of brain abnormalities associated with HIV is still poorly understood. Using parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 HIV+ participants and 31 uninfected controls. The thalamus, corpus striatum, hippocampus, amygdala, brainstem, callosum and ventricles were segmented from brain MRIs. To investigate subcortical shape, we ana…Read more