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    © 2017 Wiley Periodicals, Inc.The Sapir-Whorf hypothesis holds that human thought is shaped by language, leading speakers of different languages to think differently. This hypothesis has sparked both enthusiasm and controversy, but despite its prominence it has only occasionally been addressed in computational terms. Recent developments support a view of the Sapir-Whorf hypothesis in terms of probabilistic inference. This view may resolve some of the controversy surrounding the Sapir-Whorf hypot…Read more
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    Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells
    with T. Zhao, Z. N. Zhang, P. D. Westenskow, D. Todorova, Z. Hu, T. Lin, Z. Rong, J. Kim, J. He, M. Wang, D. O. Clegg, Y. G. Yang, K. Zhang, and M. Friedlander
    © 2015 Elsevier Inc.The breakthrough of induced pluripotent stem cell technology has raised the possibility that patient-specific iPSCs may become a renewable source of autologous cells for cell therapy without the concern of immune rejection. However, the immunogenicity of autologous human iPSC -derived cells is not well understood. Using a humanized mouse model reconstituted with a functional human immune system, we demonstrate that most teratomas formed by autologous integration-free hiPSCs e…Read more