Yuwei Xu

This paper highlights the importance of considering both researcher and participant contexts when exploring everyday educational lives. It emerges during a period of increasing and sustained social inequality in England, and against a backdrop of increasingly tight research timeframes and resources in higher education. Drawing on a project engaging low-income families in Greater London, the paper takes the everyday as its conceptual focus and questions how we can be critically attentive to everyday educational lives if we struggle to access and develop research relationships with particular social groups. We offer empirical insight into the hesitancies towards, and avoidances of, research participation that centre around knowledge, fear, and trust, and which are heightened concerns where aspects of family life, parenting, and children come to the fore. The paper considers how these can be mitigated in an academic environment where limited time and resourcing shape possibilities of research engagements and offers practical moves linked to research relationships, relevance and presence for how researchers can address these challenges to enable research to be more inclusive.

© 2017 Wiley Periodicals, Inc.The Sapir-Whorf hypothesis holds that human thought is shaped by language, leading speakers of different languages to think differently. This hypothesis has sparked both enthusiasm and controversy, but despite its prominence it has only occasionally been addressed in computational terms. Recent developments support a view of the Sapir-Whorf hypothesis in terms of probabilistic inference. This view may resolve some of the controversy surrounding the Sapir-Whorf hypothesis, and may help to normalize the hypothesis by linking it to established principles that also explain other phenomena. On this view, effects of language on nonlinguistic cognition or perception reflect standard principles of inference under uncertainty.

© 2015 Elsevier Inc.The breakthrough of induced pluripotent stem cell technology has raised the possibility that patient-specific iPSCs may become a renewable source of autologous cells for cell therapy without the concern of immune rejection. However, the immunogenicity of autologous human iPSC -derived cells is not well understood. Using a humanized mouse model reconstituted with a functional human immune system, we demonstrate that most teratomas formed by autologous integration-free hiPSCs exhibit local infiltration of antigen-specific T cells and associated tissue necrosis, indicating immune rejection of certain hiPSC-derived cells. In this context, autologous hiPSC-derived smooth muscle cells appear to be highly immunogenic, while autologous hiPSC-derived retinal pigment epithelial cells are immune tolerated even in non-ocular locations. This differential immunogenicity is due in part to abnormal expression of immunogenic antigens in hiPSC-derived SMCs, but not in hiPSC-derived RPEs. These findings support the feasibility of developing hiPSC-derived RPEs for treating macular degeneration.