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1Electron cryomicroscopy has been used to determine the atomic coordinates from density maps of biological assemblies. These models can be assessed by their overall fit to the experimental data and stereochemical information. However, these models do not annotate the actual density values of the atoms nor their positional uncertainty. Here, we introduce a computational procedure to derive an atomic model from a cryo- EM map with annotated metadata. The accuracy of such a model is validated by a f…Read more
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2Plasmon-generated hot carriers are used in photovoltaic or photochemical applications. However, the interplays between the plasmon and single-particle excitations in nanosystems have not been theoretically addressed using ab initio methods. Here we show such interplays in a Ag 55 nanocluster using real-time time-dependent density functional theory simulations. We find that the disappearance of the zero-frequency peak in the Fourier transform of the band-to-band transition coefficient is a hallma…Read more
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6© 2016, American Society for Biochemistry and Molecular Biology Inc. All rights reserved.Glycyl-tRNA synthetase is the enzyme that covalently links glycine to cognate tRNA for translation. It is of great research interest because of its nonconserved quaternary structures, unique species-specific aminoacylation properties, and noncanonical functions in neurological diseases, but none of these is fully understood. We report two crystal structures of human GlyRS variants, in the free form and in co…Read more
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3© 2014 Nature America, Inc. All rights reserved. Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated 1/42,000, 1/43,700 and 1/49,500 SNPs explained 1/421%, 1/424% and 1/429% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability.…Read more
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15Cyclic deformation and fatigue damage behaviors of oriented Ag single crystalPhilosophical Magazine 89 (32): 2903-2920. 2009.
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20Low-cycle fatigue-cracking mechanisms in fcc crystalline materialsPhilosophical Magazine 91 (2): 229-249. 2011.
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14Thermal stability of nanotwinned and nanocrystalline microstructures produced by cryogenic shear deformationPhilosophical Magazine 94 (30): 3413-3430. 2014.
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7A physical interpretation of softening of pressure-sensitive and anisotropic materialsPhilosophical Magazine 90 (19): 2569-2584. 2010.
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12Cyclic deformation and fatigue cracking behaviors of Cu–28wt%Ag binary alloyPhilosophical Magazine 89 (21): 1715-1730. 2009.
Wuhan, Hubei, China