•  9
    We describe an algorithm based on shrinkage in the curvelet domain to attenuate speckles in optical coherence tomography images. The algorithm exploits the curvelet transform's sparse representation of edge discontinuities that are common in OCT images and its ability to map signals and noise into different areas in the curvelet domain. The speckle attenuation is controlled by a single parameter that determines the threshold in the curvelet domain. Applying the algorithm to OCT images shows sign…Read more
  •  7
    Mammary gland branching morphogenesis and ductal homeostasis relies on mammary stem cell function for the maintenance of basal and luminal cell compartments. The mechanisms of transcriptional regulation of the basal cell compartment are currently unknown. We explored these mechanisms in the basal cell compartment and identified the Co-factor of LIM domains as a transcriptional regulator that maintains these cells. Clims act within the basal cell compartment to promote branching morphogenesis by …Read more
  •  20
    A new locus for dominant drusen and macular degeneration maps to chromosome 6q14
    with M. Kniazeva, E. I. Traboulsi, S. T. Stefko, M. B. Gorin, Y. Y. Shugart, O'Connell Jr, C. J. Blaschak, G. Cutting, M. Han, and K. Zhang
    PURPOSE:To report the localization of a gene causing drusen and macular degeneration in a previously undescribed North American family. METHODS:Genetic mapping studies were performed using linkage analysis in a single family with drusen and atrophic macular degeneration. RESULTS:The clinical manifestations in this family ranged from fine macular drusen in asymptomatic middle-aged individuals to atrophic macular lesions in two children and two elderly patients. We mapped the gene to chromosome 6q…Read more