•  14
    Searching in Dual Worlds
    Journal of Intelligent Systems 9 (1): 55-74. 1999.
  •  4
    IPCC, 2007: Summary for Policymakers
    with D. Qin, K. B. Averyt, H. L. Miller, S. Solomon, M. Manning, M. Marquis, and M. Tignor
    In S. Solomon, D. Qin, M. Manning, Z. Chen, M. Marquis, K. B. Averyt, M. Tignor & H. L. Miller (eds.), Climate Change 2007: The Physical Science Basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change, Cambridge University Press. 2007.
  •  2
    Use of polar decomposition for the diagnosis of oral precancer
    with J. Chung, W. Jung, M. J. Hammer-Wilson, and P. Wilder-Smith
    The Mueller matrix describes all the polarizing properties of a sample and, therefore, the optical differences between noncancerous and precancerous tissue that may be present within the matrix elements. A high-speed polarimetry system that generates 16 full Mueller matrices to characterize tissues is presented. Feature extraction is done on the Mueller matrix elements resulting in depolarization and retardance images by polar decomposition. These are used to detect and classify early oral cance…Read more
  •  2
    Background: Optical Doppler tomography combines laser Doppler flowmetry with optical coherence tomography to obtain high-resolution images of blood flow in human skin in situ and in real time. Observations: We present a case in which ODT was used on a patient with a port-wine stain birth-mark to document the change of blood flow in response to laser therapy. It might be possible to use ODT blood flow measurements in situ to assist in assessing the efficacy of laser PWS therapy. If partial restor…Read more
  •  1
    Global climate projections
    with S. Solomon, D. Qin, M. Manning, M. Marquis, K. B. Averyt, M. Tignor, and H. L. Miller
    In S. Solomon, D. Qin, M. Manning, Z. Chen, M. Marquis, K. B. Averyt, M. Tignor & H. L. Miller (eds.), Climate Change 2007: The Physical Science Basis. Contribution of Working Group I to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change, Cambridge University Press. 2007.
  • Background: In vivo, non-invasive optical coherence tomography permits high-resolution imaging of tissue surfaces and subsurfaces, with the potential capability for detection and mapping of epithelial pathologies. Purpose: To evaluate the clinical capability of non-invasive in vivo OCT for diagnosing oral dysplasia and malignancy. Experimental Design: In 50 patients with oral lesions, conventional clinical examination was followed by OCT imaging, then standard biopsy and histopathology. Two blin…Read more
  • Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imaging
    with K. C. Hoang, A. Edris, J. Su, D. S. Mukai, S. Mahon, A. D. Petrov, M. Kern, C. Ashan, B. J. Tromberg, J. Narula, and M. Brenner
    Optical coherence tomography is a catheter-based imaging technology with powerful resolution capable of identifying vulnerable plaques and guiding coronary intervention. However, a significant limitation of intravascular OCT imaging is its attenuation by blood. We propose that the use of an oxygen-carrying blood substitute could potentially optimize OCT image quality. Surgical isolation of the descending thoracic aorta of six rabbits is performed, followed by intravascular OCT imaging of the abd…Read more
  • Noninvasive imaging of oral premalignancy and malignancy
    with P. Wilder-Smith, T. Krasieva, W. G. Jung, J. Zhang, K. Osann, and B. Tromberg
    Early detection of cancer and its precursors remains the best way to ensure patient survival and quality of life. Our specific aim is to test a multimodality approach to noninvasive diagnostics of oral premalignancy and malignancy. In the hamster cheek pouch model, in vivo optical coherence tomography and optical Doppler tomography map epithelial, subepithelial, and vascular change throughout carcinogenesis. In vivo multiwavelength multiphoton and second-harmonic generated fluorescence technique…Read more