•  2
    Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity
    with Y. Hu, N. Ru, H. Xiao, A. Chaturbedi, Hoa N. T., X. J. Tian, H. Zhang, C. Ke, F. Yan, J. Nelson, R. Gramer, L. Yu, E. Siegel, X. Zhang, Z. Jia, M. R. Jadus, C. L. Limoli, M. E. Linskey, J. Xing, and Y. H. Zhou
    Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 copy number variation in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in high-grade gliomas carrying more than 2 copies of Chr7, as compared to low-grade gliomas. Interestingly, all Chr7-aneuploid cell types in the parental culture of established glioma cell lines reappeared in single-cell-…Read more