Maria Lopez

The versatile clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has emerged as a promising technology for therapy and molecular diagnosis. It is especially suited for overcoming viral infections outbreaks, since their effective control relies on an efficient treatment, but also on a fast diagnosis to prevent disease dissemination. The CRISPR toolbox offers DNA‐ and RNA‐targeting nucleases that constitute dual weapons against viruses. They allow both the manipulation of viral and host genomes for therapeutic purposes and the detection of viral nucleic acids in “Point of Care” sensor devices. Here, we thoroughly review recent advances in the use of the CRISPR/Cas system for the treatment and diagnosis of viral deleterious infections such as HIV or SARS‐CoV‐2, examining their strengths and limitations. We describe the main points to consider when designing CRISPR antiviral strategies and the scientific efforts to develop more sensitive CRISPR‐based viral detectors. Finally, we discuss future prospects to improve both applications. Also see the video abstract here: https://www.youtube.com/watch?v=C0z1dLpJWl4.

La enseñanza de las confrontaciones producidas a lo largo del siglo XX, y en especial durante la Segunda Guerra Mundial sigue siendo un tema controvertido en la didáctica de las Ciencias Sociales. Tomando como referencia el currículo de cuarto de la ESO, y en especial el bloque décimo de la materia de Geografía e Historia, esta comunicación selecciona una serie de materiales didácticos cartográficos de indudable utilidad en los procesos de enseñanza-aprendizaje de la relación entre el pasado, el presente y la proyección al futuro a través de estas dos disciplinas referentes. Además del estándar de aprendizaje referido al Holocausto, esta propuesta didáctica –fundamentada en los proyectos europeos Youthmetre y EuropeanValuesStudy- procura dar cumplimiento a la comprensión de las causas por las que una Europa en guerra durante el siglo XX ha podido llegar a una unión económica y política en el siglo XXI.

The article analyzes three different cases of clinical research in which children are asked to participate. Participation of children in researches is one of the major challenges for Bioethics and societies nowadays due to the tensions and issues concerning the guarantee of rights in clinical research, the responsibilities of the different actors involved, and the purpose of improving the quality of life without affecting scientific freedom and new knowledge production. The aim of the article is to establish the way in which autonomy is exercised, considering ethical and regulative aspects within clinical research involving children. In order to achieve such a purpose, case study research methodology is employed, revealing the tensions and ethical issues involved in this particular kind of clinical research as well as considering international documents and the national regulation regarding this particular problem.

Introduction: Loss of employment is an experience that is lived and interpreted differently depending on a series of individual variables, including the psychological resources available to the affected person, as well as their perception of their degree of employability. Losing one’s job can be one of the most painful and traumatic events a person has to withstand. Following a dismissal, the worker needs to overcome a period of emotional adaptation to the loss. But that period of grieving can also condition the process of job search of the person, and be influenced by different variables, highlighting the age and work experience. The objective of this study is to analyze the relationship between intensity and type of affliction due to the loss of employment in older workers and their level of employability. Method: We carried out a descriptive, analytical, cross-sectional study. The sample consisted of 140 unemployed participants, from 19 to 65 years of age, users of job Orientation in the Public Employment Service of Andalusia (España). Of the total participants, 66 were unemployed and over 45 years of age. They all took the Labour Insertion Potential Assessment Test, and the Texas Inventory revised adapted to job loss Results: Significant differences are shown in the grieving process due to loss of employment between both groups, with the older unemployed living the process more intensely. In relation to the employability potential, differences are found between both groups in terms of availability, perceived difficulties and fears. Interrelationships between total grieving intensity and the importance that older jobseekers give to work are also indicated. Conclusion:Loss of employment and the psychological and health consequences of this situation are identified with those that arise in the grieving process. Older workers present a series of features that determine that their job loss grieving process is more intense and lasts longer than that of other younger workers, regardless of whether the job loss was recent or not. On the other hand, it is shown that the intensity of grieving is related to the decrease of certain variables that are part of the concept of employability.

El mito del hombre nuevo y la realidad de las leyes. RESEÑA de : Fernández Liria, Carlos; Alegre Zahonero, Luís. Comprender Venezuela : pensar la democracia : el colapso moral de los intelectuales occidentales. Hondarribia : Editorial Hiru, 2006. RESEÑA de : Arnau, Juan. La palabra frente al vacío : filosofía de Nágárjuna. México : Fondo de Cultura Económica, 2005. RESEÑA de : Galilei, Galileo. Carta a Cristina de Lorena y otros textos sobre ciencia y religión. Madrid : Alianza editorial, 2006. RESEÑA de : González García, Moisés (compilador). Filosofía y dolor. Tecnos, 2006. RESEÑA de : París, C. Medio siglo de memoria. Barcelona : Península, 2006.

There is an increasing demand for ethical and Corporate Social Responsibility practices by companies. This competence has to be introduced in students’ training in business degree programs, and a check must then be done to determine if the students have come to appreciate the importance of CSR commitments. Using the framework of Stakeholders Theory, this work aims to examine students’ perceptions of ethical and CSR practices and commitment to different stakeholders, as well as the factors that lead students to act in a socially responsible way. Furthermore, we hope to identify how the perception of CSR can be improved when Web 2.0 and social media tools that have proven effective in transmitting emotions and values are used in classrooms to teach these ideas. To this end, a survey was carried out in the year 2019 with 1,030 first-year students; it was administered at the beginning of the semester and also at the end of the semester after the training activities had been carried out. The main finding of the research is that students start with the belief that ethics and CSR are developed for reasons of image and legitimacy; however, after receiving training on these topics through tools that take into account emotions and values, they start to value the importance of the company as an agent of social change. The main practical and managerial implication is that methods based on Web 2.0 and social media tools are useful to teach ethics and CSR; the theoretical contribution is that students take into account the welfare of others. This finding contributes to Stakeholder Theory in a higher education context.

El presente artículo se centra en el estudio de varias experiencias basadas en dinámicas de presupuestos participativos y dirigidas a niños, niñas y adolescentes. Esta investigación recogió datos de las principales experiencias participativas en el ámbito de la Provincia de Alicante durante el periodo 2015-2022 a través de una encuesta y de una búsqueda de documentación relacionada. Los datos provenientes de los ayuntamientos han sido tratados a través del programa MAXQDA. Entre los principales resultados, se puede destacar las distintas percepciones que tienen los participantes del concepto y la necesidad de ahondar en instrumentos de esta naturaleza.